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Tuesday, April 12, 2011

Spirochetes Have Little Feet ( The Mythology of Microbiology)

By Lea

Before microbiology,
Bacteria were mythology.
Demons, humors, tainted blood,
No one knew just what was what.

But thanks to Dr. Levenhook,
Mankind got a closer look.
Now we see, and oh so clear,
 That microbes are, like, Everywhere!

And thanks to Dr. Kaiser,
Our world is so much wiser.
We know how to identify
Those things which quickly multiply.

And how to know the difference
'tween the ‘cillins and the 'mixins,
And how to make a heat fixed stain,
And isolate resistant strains.

Gram positives with nag and nam,
And cross linked peptide bonds,

Staph Aureus

Gram negatives with LPS,
Endospores that outlive bombs.

Molds with hyphae, vegetative,
Molds with canidiaspores.
Molds that aren't cooperative,
Hide in endospores!

Staph Aurous grown on people's skin,  
Enterococcus likes to hang within ,
E. Coli chills inside the gut,
If it migrates foreword, you wee a lot.

Another of my favorites is t. pallidum,
You don't want to meet
This syphilus-y spirochete
( STD's can be  a bum.)


Streptococcus pyogenes
can make a throat so red,
If the latex clumps on a direct s test,
Its amoxicillin and straight to bed!

Microsporum tuburculae oh what a nasty thing,
It fills the lungs with tubercles
That make it hard to sing

Be careful when you go outside,
Or when you play in dirt.
Beware of cuts from rusty nails,
Clostridium tetany sure can hurt !

Pneumocystis jirovecii,
A dimorphic bird poop mold,
Can cause respiratory pcp,
In those with HIV, and in the old. 

To speak of Candida Albicans
Requires some finess-es,
The mere mention of its yeastly name
Can petrify we who wear  dresses.

Candida Albicans

But if that little friendly yeast
Gets all comfy where he's welcome not 
Ergosterol inhibitors; what a relief!
Clotrimazole hits the spot.

There are so many different ways
To keep those nasty bugs at bay :

Static, cidal, fungicidal
So many things microbicidal.

It's hard to know which one to choose,


Some strains will win and some will lose.

But a Bauer Kirby diskette test
Can let you know which agent's best.

And if you ever want to know,
Just which pathogen ails one so,
Phage typing is the way to go.
To find out just which microbe
Is replicating to and fro.
Just stamp your innoculum with a disk
Then look for the inhibbited zones.

Ain’t it just so darn terrific
The way phages are bacterio-specific?
Ain't it awsome peachy
That we can detect things that are sneaky?

So, you should be glad to know...

That inflammation is something …
That everyone must do,
To increase capillary permeability,
And bring lymph cells to tissue.

So don't have a bad attitude,
If you get sick have gratitude!
Innate Immunity will get you through,
Until adaptive systems  knows what to do.

Antigen presenters play the game of show and tell,
Bringing epitopes to killers, 
making cytotoxic cells.

By presenting all the things they've got
They help T- cells mature,
Into the type that can lyse cells,
Or act as effectors.

Natural killers roam around,
Looking for bad guys.

B Cells Communicate with T Cells via cytokines

If they spot a stressed or tumor cell,
They'll shoot him 'tween the eyes.

But first they check to see if he
Displays his stuff on MHC.
For even if the signal says,
To kill the bad cell, shoot it dead,

If MHC is exhibited,
Then that signal is inhibited,

But don't you worry, never fret,
That trick won't last long, don't forget,
That B cells don't care all that much,
Just how cells show them what they've got.

For antigens can bind cells "B,"
Without a fancy MHC

  And when B-cells meet their perfect mate,
They can become something so great!



Cuz when the opsonizing starts,
And CB3 binds B's "2" part,
It isn't long, oh bless my heart!
'Till naive B's transforms themselves,
To antibody secreting plasma cells.

Isn't it incredible,
How some cells are edible?
Isn't it terrific
That adaptive cells are so specific?

Doesn't it make you cheery
That confused self-antigen binders
commit harikiri?

Now that we are so much wiser,
Let’s say "Thanks!" to Dr. Kaiser
For helping us get oh, so knowledgy
About the wonders of microbiology!

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